Silymarin, Natural Flavonolignans from Milk Thistle
نویسنده
چکیده
Plants are a valuable source of pharmaceuticals, food ingredients, agrochemicals, insecticides, flavors and pigments. These compounds are called secondary metabolites. These are compounds with a restricted occurrence in taxonomic groups that are not essential for an organism to live but play a role in the interaction of the organism with its environment, ensuring the survival of the organism in its ecosystem (Verpoorte and Alfermann, 2000).
منابع مشابه
Flavonolignans from Aspergillus iizukae, a fungal endophyte of milk thistle (Silybum marianum).
Silybin A (1), silybin B (2), and isosilybin A (3), three of the seven flavonolignans that constitute silymarin, an extract of the fruits of milk thistle (Silybum marianum), were detected for the first time from a fungal endophyte, Aspergillus iizukae, isolated from the surface-sterilized leaves of S. marianum. The flavonolignans were identified using a UPLC-PDA-HRMS-MS/MS method by matching re...
متن کاملPharmacokinetics and metabolic profile of free, conjugated, and total silymarin flavonolignans in human plasma after oral administration of milk thistle extract.
Silymarin, a mixture of polyphenolic flavonoids extracted from milk thistle (Silybum marianum), is composed mainly of silychristin, silydianin, silybin A, silybin B (SB(B)), isosilybin A (ISB(A)), and isosilybin B. In this study, the plasma concentrations of free (unconjugated), conjugated (sulfated and glucuronidated), and total (free and conjugated) silymarin flavonolignans were measured usin...
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Radiotherapy is the most common cancer treatment modality applying ionizing radiation. In majority of the cases, RT necessarily affects on normal tissues around the tumor. Silymarin is one of the most important chemical ingredients of the milk thistle. Silymarin composed of six flavonolignans that Silibinin, with 40-50%, is the most one. In view of the innumerable beneficial effects of silymari...
متن کاملMilk Thistle and the Liver: Recent Findings
The standardized extract contains flavonolignans, collectively referred to as silymarin. Sometimes the extract itself is called “silymarin”, which can lead to confusion over dosage since the level of flavonolignans (silymarin) in the extract is typically 60 to 80%, depending on the test methodology used. The main flavonolignans found in the extract are silybin (silibin), silychristin, silydiani...
متن کاملMilk thistle in liver diseases: past, present, future.
Silybum marianum or milk thistle (MT) is the most well-researched plant in the treatment of liver disease. The active complex of MT is a lipophilic extract from the seeds of the plant and is composed of three isomer flavonolignans (silybin, silydianin, and silychristin) collectively known as silymarin. Silybin is a component with the greatest degree of biological activity and makes up 50% to 70...
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